منابع مشابه
A combination therapy for KRAS-mutant lung cancer by targeting synthetic lethal partners of mutant KRAS
The KRAS gene is frequently mutated in multiple cancer types, but it fell off the drug discovery radar for many years because of its inherent "undruggable" structure and undefined biological properties. As reported in the paper entitled "Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK" in Nature Communications, we performed a synthetic lethal screeni...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2013
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn3573